Wellcome’s Mental Health Active Ingredients 2021 Request for Proposals

Posted on February 3, 2021

Wellcome’s Mental Health Active Ingredients 2021 Request for Proposals


Wellcome is delighted to announce the launch of our Active Ingredients 2021 Request for Proposals. Starting with anxiety and depression in young people, Wellcome is determined to transform how we understand, fund and address mental health problems by 2030. Our vision is a world in which no one is held back by mental health problems.

This commission will be our second exploring ‘Active Ingredients’ – the aspects of interventions that really make a difference to prevent, treat and manage anxiety and/or depression in young people (aged 14-24) worldwide.

In 2020, 30 research teams reviewed the evidence for 26 Active Ingredients they deemed most important. The Active Ingredients reviewed were diverse, spanning from the cellular to the societal; the selected findings are available here. 

Now we seek to commission up to 20 teams to review ONE Active Ingredient not included in those reviewed in the 2020 commission. Our intention is to commission at least five from low- and middle-income countries. The commission will be undertaken between June and November 2021.

Integrating the perspectives of young people with lived experience will be key. And so long as one team member has a broadly defined mental health science background, applications from any global location, sector and career stage are encouraged.

For full details:

See our Request for Proposals (RFP)

Register for our webinar on 9 February

Submit questions via email by 17:00 GMT 12 February

Complete an Expression of Interest by 12:00 GMT 8 March 2021